Mitosis is a more regulated process in which the chromosome number is regulated by a checkpoint in metaphase.
Binary fission sometimes results in the duplication of the chromosomes which leads to increase in the number of chromosomes in the cell and hence is a less reliable process. In binary fission, the cell membrane attaches the DNA whereas in mitosis, the DNA is attached to the spindle fibers and not cell membranes. On the other hand, in eukaryotes, mitosis is the main mode of growth, development and regeneration. Binary fission is the main mode of asexual reproduction in prokaryotes. Mitosis does not have different types like binary fission. There are several types of binary fission, these include simple binary fission for example in amoebas, transverse as in paramecia and planarians, longitudinal as in euglenas and oblique as in marine dinoflagellates. Cellular components like ribosomes are doubled before the binary fission whereas in mitosis, the organelles doubles at the interphase, which is a part of mitosis. On the other hand, mitosis consists of four distinct stages or phases called prophase, prometaphase, metaphase, anaphase, and telophase. Binary fission does not include multiple stages. Binary fission does not include sister chromatids whereas mitosis involves sister chromatids. Binary fission is a simple process of cell division whereas mitosis is a complex process involving multiple steps. Binary fission is much faster than mitosis. The process of binary fission does not include spindle formation whereas the mitosis includes spindle formation. In mitosis, the cell division is vegetative. In binary fission, a single cell divides into two daughter cells. Binary fission is a process of cell division in prokaryotes (the cells that do not have nucleus) whereas mitosis takes place in eukaryotes (the cells that have a well-defined nucleus). What are the major differences between binary fission and mitosis? Higher organisms like fungi, plants and animals including humans, use mitosis as one of their modes of cell division. 
It has several phases like prophase, prometaphase, metaphase, anaphase and telophase. It involves the mitosis spindles and sister chromatids for cell division and segregation. Mitosis is mainly important for growth, development and regeneration of cells, although it is also used for asexual reproduction. Mitosis is a type of cell division that takes place in eukaryotes. Unicellular organisms like amoeba and paramecium reproduce by binary fission.
It can be of several types like simple, transverse, longitudinal and oblique binary fission. It is faster than other forms of cell division. It is one of the simplest form of asexual reproduction. Binary fission literally means division in half. Difference between Binary Fission and Mitosisīinary fission is the primary mode of reproduction in prokaryotes.
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